KITP program on Memory Formation in Matter Santa Barbara, 11 January 2018
Immunological Memory & Immunological Tolerance
Andrej Kosmrlj, Hanrong Chen
Tom Butler, John Barton, Assaf Amitai, Shenshen Wang
Abhishek Jha, Eugene Shakhnovich, Eric Huseby, Arup K. Chakraborty
Mehran Kardar (MIT)
Outline
I. Introduction: B cells, T cells, receptors, thymic selection
II. Model & Analysis: binding, positive and negative selection, Exterme Value Distribution, exact enrichment factors
III. Results and experiments: specificity and self-reactivity, amino-acid bias, contact profiles
IV. Quorum sensing as a means for avoiding autoimmune response
V. Summary