Summary

I.       Introduction: B cells, Antibodies and antigens                      

         the puzzle of low HIV spike density                           

II.      Affinity Maturation: Evolution in the Germinal Center  (bnAbs)

III.      Fitness & Evolution: Competition for virus capture

dependence of potency on spike density   

IV.     Optimal density for synthetic nanoparticle vaccination; increased competition in HIV

A. Amitai, A.K. Chakravorty, M. Kardar PLOS Comp. Bio. doi.org/10.1371/journal.pcbi.1006408

Simons Workshop on                                  Nonequilibrium Physics in Biology                 Stony Brook, 5 December 2018

         Assaf Amitai               Shenshen Wang           Arup K. Chakraborty

Next (Introduction) Outline Introduction Affinity Maturation Fitness & Evolution Optimal density Summary