Protease

HIV-1 protease is a homodimer of 99 amino-acids: (wikipedia)

Cleavage of polyproteins is essential to HIV lifecycle

Protease Inhibitors bind to the active site: (wikipedia)

Resistance mutations lead to drug resistance: [Molla et al, Nature Medicine 2, 760 (1996)]

Mutations appear reproducibly at sites 82, 54, 71.

Next (Sequence) Outline HIV Protease Sequence Resistance sites Summary